Octopus
Networks
-
Datasets
-
Variables
-
The main goals of the OCTOPUS project are the following:
- to determine, in genetically modified mouse models, to what extent different levels of apoA-I/HDL modulate gut microbiota composition, intestinal homeostasis/immunity, plasma metabolome and atherosclerosis development.
- to determine whether apoA-I/HDL levels can modulate gut microbiota composition and plasma metabolome in human cohorts, and to identify possible correlations between microbiota composition and metabolic parameters.
- to conduct SNPs analyses to highlight polymorphisms in genes involved in the microbiota-host cross-talk which could influence apoA-I/HDL levels.
- to disseminate to the general public, scientific community, and stakeholders the scientific questions, aims, initiatives and results of the project.
- Start Year
- 2018
- End Year
- 2022
- Funding
- JPI HDHL-INMTIMIC
Visit OCTOPUS
| Investigators | Contacts |
|---|---|
|
Design
- Study design
- Cohort
Recruitment
- Sources of Recruitment
-
- Individuals
Number of participants
- Number of participants
- 131
- Number of participants with biosamples
- 131
Timeline
octopus
Selection Criteria
- Newborns
- Twins
- Countries
-
- Italy
- International/National/Regional (region name)
- Europe
- Ethnic Origin
-
- Health Status
-
Recruitment
- Sources of recruitment
-
- General population
- General Population
-
- Volunteer enrolment
Number of participants
- Number of participants
- 131
- Number of participants with biosamples
- 131
Data Collection Event
- Start Date
-
2018
- End Date
-
2022
-
Measurements & methods
-
Dietary intake
- yes/no
-
- Information collected on habitual food intake collected
- Information collected on type of diet (vegetarian/vegan/omnivore)
- Methods
-
- Other methods
-
Other methods
- Other methods
- Questionnaires
-
Anthropometric measurements
- Weight/height
- Measured
- Waist/hip circumference
- Measured
-
Health status
- Information collected
- Several, focused on cardiovascular and metabolic data, family history of CVD and related diseases
-
Biological samples and laboratory measurements
- Samples collected
- Blood, stool
- Number of samples
- 131
-
Biomarkers
-
Lipids
- Measurement(s)
- Various
- Medium
- Plasma
-
Glucose
- Measurement(s)
- Various
- Medium
- Plasma
-
Inflammation markers
- Measurement(s)
- Various
- Medium
- Plasma
-
Other biomarkers
- Measurement(s)
- Various
-
Metabolomics
- Medium
- Plasma, stool
- Untargeted approach
- yes
- Targeted groups
- Several: TMAO, SCFA, etc.
-
Genomics
- DNA available
- yes
- Number of samples/number of individuals
-
131
- Genotyping
- SNPs
-
Microbiome
- Microbial material
- 16S (V3–V4)
- Number of samples/number of individuals
-
130
- Library source and library selection
- Faeces
- Sequencing platform
- Illumina MiSeq