NAKO Gesundheitsstudie (German National Cohort)
Networks
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Datasets
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Variables
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The “NAKO Gesundheitsstudie” (German National Cohort, NAKO) is a large-scale, nationwide, long-term population-based cohort study that aims at investigating the causes of widespread diseases, identifying risk factors and highlighting effective forms of early detection and prevention of disease. Between 2014-2019, a total of 205,217 individuals aged 20-69 yrs from across Germany were medically examined and questioned on their living habits in 18 study centers using the same protocols and equipment. All participants supplied blood samples, which are stored in a central biobank as well as in decentral biorepositories for later research projects. Whole-body 3T MRI readings on dedicated scanners were performed on 30,861 participants at 5 sites. Five years after their baseline assessment, all participants are invited for a second examination, starting in 2019. A third examination is in the planning phase. Participants are being followed-up via active and passive follow-up procedures, which will make it possible to study the association of baseline risk factors with risk of major chronic disease and death. Active follow-up includes among others, the use of questionnaires, which are sent to participants every 2-3 years. Passive follow-up includes the integration of secondary data from different sources, including health and retirement insurances and mortality registries. NAKO data is made available upon application to interested researchers via a transfer unit. Taken together, the NAKO provides unique health research data to deepen our understanding of disease aetiology and to support prevention, early disease detection and treatment.
- Start Year
- 2014
- Funding
- German Federal Ministry of Education of Research, States of Germany, and the Helmholtz Association
Visit NAKO
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Design
- Study design
- Cohort
- Follow Up
- yes, 20-30 years, ongoing.
Marker Paper
German National Cohort (GNC) Consortium. The German National Cohort: aims, study design and organization. Eur J Epidemiol. 2014 May;29(5):371-82. German National Cohort (NAKO) Consortium. Framework and Baseline Examination of the German National Cohort (NAKO). Eur J Epidemiol, in press
PUBMED 24840228
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 205,217
- Number of participants with biosamples
- 205,217
- Supplementary Information
- men/women = 50/50 MDC, 10110 participants
Timeline
NAKO population
NAKO baseline population, recruited in 2014-2019, based on random samples retrieved from municipal registries, stratified on age (10% in each 10-year group between 20 and 39 years, and 26.67% in each 10-year group between 40 and 69 years) and sex (50% women, 50% men).
Selection Criteria
- Minimum age
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20
- Maximum age
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69
- Newborns
- Twins
- Countries
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- Germany
- International/National/Regional (region name)
- National (Germany)
- Ethnic Origin
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- General population
- Health Status
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- General population
- Supplementary Information
- population-based, stratified random sampling in predefined study regions
Recruitment
- Sources of recruitment
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- General population
Number of participants
- Number of participants
- 205,217
- Number of participants with biosamples
- 205,217
Data Collection Event
- Start Date
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2014
- End Date
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2019
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Measurements & methods
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Dietary intake
- yes/no
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- Information collected on habitual food intake collected
- Special dietary aspects collected (e.g. supplements, probiotics, prebiotics and synbiotics)
- Methods
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- 24-hour dietary recall
- FFQ
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24-hour dietary recall
- Administration method
- Self-reported
- Administration type
- Web/computer-based
- Number of recalls
- 2-7
- Portion size estimation
- Not quantified
- Instrument development
- Short food list
- Instrument reference
- Freese J,et al., Eur J Clin Nutr. 2014 Mar;68(3):324-9.
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FFQ
- Questionnaire name/set of questions
- German FFQ /DIfE
- Type of questionnaire
- Semi-quantitative
- Administration method
- Self-reported
- Administration type
- Web/computer-based
- Reference period
- Year
- Frequency categories
- 6
- Instrument reference
- Boeing H et.al., Int J Epidemiol 1997;26 Suppl 1:S82-90 ; Bohlscheid-Thomas S et.al., Int J Epidemiol 1997;26 Suppl 1:S59-70 ; Bohlscheid-Thomas S et.al., Int J Epidemiol 1997;26 Suppl 1:S71-81 ; Kroke A et.al., Am J Clin Nutr 1999 Oct;70(4):439-47
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Alcohol consumption
- Information collected
- Frequency of consumption of alcoholic drinks
- Questionnaire name/set of questions
- Set of questions
- Administration method
- Self-reported
- Administration type
- Web/computer-based
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Tobacco consumption
- Information collected
- Frequency of smoking cigarettes and other tobacco products; exposure to indoor toboacco smoke
- Questionnaire name/set of questions
- Set of questions
- Administration method
- Self-reported
- Administration type
- Web/computer-based
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Physical activity
- Information collected
- Frequency, duration and types of PA
- Questionnaire name/set of questions
- Set of questions
- Device type
- Actigraph
- Device model
- GTX3
- Measurement period
- 7 days
- Measurement position
- Hip
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Sedentary behaviours
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Anthropometric measurements
- Weight/height
- Measured
- Waist/hip circumference
- Measured waist circumference
- Other measurements
- Body composition (BIA), abdominal fat mass (ultrasonography)
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Sociodemographic information
- Information collected
- Sex, age, residence, country of birth, country of citizenship at time of data collection, marital status, economic income status, etc.
- Questionnaire name/set of questions
- Set of questions
- Administration method
- Face-to-face interview
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Medication
- Information collected
- PZN-Code for each medication->drug name & ATC code
- Questionnaire name/set of questions
- Scan of medication labels
- Antibiotics
- Last treatment and frequency collected
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Health status
- Information collected
- Diseases: autism, celiac disease, cardiovascular disease, cancer, diabetes, respiratory disease, chronic infectious disease, neurodegenerative disease; pre-clinical mesaurements: subclinical atherosclerosis, cardiac dysfunction, blood pressure, glucose tolerance, advanced glycation end products, retinopathy, olfactory function, lung function/volume, immune function, athrosis, rheumatoid arthritis
- Administration method
- Face-to-face interview
- Administration type
- Web/computer-based
- Measurements
- Various
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Biological samples and laboratory measurements
- Samples collected
- Blood, urine, nasal swabs, saliva, stool
- Number of samples
- 205217
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Biomarkers
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Lipids
- Measurement(s)
- HDL-C, LDL-C, total cholesterol, triglycerides
- Medium
- Serum
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Glucose
- Measurement(s)
- Glucose, HbA1c
- Medium
- Serum (glucose), EDTA (HbA1c)
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Inflammation markers
- Measurement(s)
- Leukocytes, CRP
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Genomics
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Microbiome