MetaCardis
Networks
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Datasets
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Variables
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MetaCardis is a major EU-funded research project investigating the role of gut microbes in cardiometabolic diseases (CMDs). The main investigatory approach is metagenomics and the use of clinical and experimental studies.
- Start Year
- 2013
- End Year
- 2015
- Funding
- EU FP7
Visit MetaCardis
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Design
- Study design
- Cross-sectional
- Follow Up
- No
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 2,189
- Number of participants with biosamples
- Supplementary Information
- 1101 M 1088 F
Timeline
MetaCardis population
Selection Criteria
- Minimum age
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18
- Maximum age
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75
- Newborns
- Twins
- Countries
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- Germany
- France
- Denmark
- International/National/Regional (region name)
- Europe
- Ethnic Origin
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- Health Status
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- Multiple graduated groups ranging from healthy, metabolic syndrome, obese, morbidly obese, T2D, acute CAD, chronic CAD w/o HF, chronic CAD w HF, HF w/o CAD
Recruitment
- Sources of recruitment
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- General population
- Other : Recruitment through clinics and through advertisement (for controls)
Number of participants
- Number of participants
- 2,189
- Number of participants with biosamples
- 2,189
- Supplementary Information
- 1101 M 1088 F
Data Collection Event
- Start Date
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2013
- End Date
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2015
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Measurements & methods
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Dietary intake
- yes/no
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- Information collected on habitual food intake collected
- Information collected on type of diet (vegetarian/vegan/omnivore)
- Methods
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- 24-hour dietary recall
- FFQ
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24-hour dietary recall
- Instrument development
- 24h was done in subset of subjects to validate FFQ
- Instrument reference
- https://www.ncbi.nlm.nih.gov/pubmed/28024800
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FFQ
- Questionnaire name/set of questions
- MetaCardis FFQ
- Type of questionnaire
- Semi-quantitative
- Administration method
- Self-reported
- Administration type
- Web/computer-based
- Number of food items
- Country-dependent
- Reference period
- Varying
- Frequency categories
- Varying
- Portion size estimation
- Standard portion sizes without aids
- Reproducibility
- Tested
- Instrument validity
- Tested
- Instrument development
- Newly developed
- Instrument reference
- https://www.ncbi.nlm.nih.gov/pubmed/28024800
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Alcohol consumption
- Questionnaire name/set of questions
- Set of questions
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Tobacco consumption
- Questionnaire name/set of questions
- Set of questions
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Physical activity
- Information collected
- Various
- Questionnaire name/set of questions
- Set of questions
- Administration method
- Face-to-face interview
- Domains covered
- Leisure, occupation
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Sedentary behaviours
- Questionnaire name/set of questions
- Set of questions
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Anthropometric measurements
- Weight/height
- Measured
- Waist/hip circumference
- Waist circumference (measured)
- Other measurements
- Various
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Sociodemographic information
- Information collected
- Sex, age, residence, country of birth, country of citizenship at time of data collection, economic income status, education, etc.
- Questionnaire name/set of questions
- Set of questions
- Administration method
- Face-to-face interview
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Medication
- Information collected
- Drug dosage and drug name
- Questionnaire name/set of questions
- Medical records
- Antibiotics
- Last treatment and frequency collected
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Health status
- Information collected
- Various, focused on CMD and comorbidities
- Questionnaire name/set of questions
- Various
- Administration method
- Face-to-face interview
- Measurements
- Various
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Biological samples and laboratory measurements
- Samples collected
- Blood, urine, stool
- Number of samples
- 2189
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Biomarkers
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Lipids
- Measurement(s)
- Various
- Medium
- Serum
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Glucose
- Measurement(s)
- Various
- Medium
- Serum
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Inflammation markers
- Measurement(s)
- Various
- Medium
- Serum
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Adiposity biomarkers
- Measurement(s)
- Various
- Medium
- Serum
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Other biomarkers
- Measurement(s)
- Various
- Medium
- Serum
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Metabolomics
- Measurement(s)
- NMR, HP-LC, others
- Medium
- Serum, urine
- Untargeted approach
- yes
- Targeted groups
- Several: lipids, aminoacyls, others
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Microbiome
- Microbial material
- DNA, shotgun
- Number of samples/number of individuals
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2,189
- Library source and library selection
- Metagenome, serum and urine metabolome
- Medium/tissue
- Faeces
- Sampling collection method
- Samples on dry ice
- Time spent in room temperature
- None
- Sequencing platform
- Ion-Proton
- Read length/depth
- ~150/23M+-4M
- Further details
- Shotgun metagenome
- Preservation method
- Immediate -20, dry ice/-80 within 4-24h
- Information on type of meal last eaten prior to sample extraction available
- no