Individual Study / Infant microbiome studies (full term, moderately preterm and preterm infants with VLBW)

Infant microbiome studies, including full term, moderately preterm and preterm infants with very low birthweight
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Infant microbiome studies, including full term, moderately preterm and preterm infants with very low birthweight

Networks -
Datasets -
Variables -
Start Year
2013
End Year
2015
Funding
Italian Ministry of Education, University and Research, within the National Technological Cluster project PROS.IT
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Members

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Investigators Contacts
  • Marco Fabbrini
    University of Bologna

Design

Study design
Other
Follow Up
yes, 210 days

Marker Paper

Full term: https://www.frontiersin.org/articles/10.3389/fmicb.2017.01214/full DOI: 10.3389/fmicb.2017.01214 Moderately preterm: https://www.frontiersin.org/articles/10.3389/fmicb.2018.02512/full DOI: 10.3389/fmicb.2018.02512 VLBW: https://link.springer.com/article/10.1007/s00431-021-04327-1 DOI: 10.1007/s00431-021-04327-1

PUBMED Full term: 28713343, Preterm: 30405571, VLBW:34842970

Recruitment

Sources of Recruitment
  • Individuals
  • Families

Number of participants

Number of participants
87
Number of participants with biosamples

Timeline

nfant-microbiome-studies_-including-full-term_-moderately-preterm-and-preterm-infants-with-very-low-birthweight

Selection Criteria
Minimum age
0
Maximum age
0
Pregnant women
  • Third Trimester
Newborns
Twins
Countries
  • Italy
International/National/Regional (region name)
National
Ethnic Origin
Health Status

Recruitment

Sources of recruitment
  • General population

Number of participants

Number of participants
87
Number of participants with biosamples
Data Collection Event
Start Date
2013
End Date
2015

Measurements & methods

Dietary intake

yes/no
  • Information collected on habitual food intake collected
  • Special dietary aspects collected (e.g. supplements, probiotics, prebiotics and synbiotics)
Methods
  • Other methods
Other methods
Other methods
Interview or visit

Anthropometric measurements

Weight/height
Measured

Sociodemographic information

Information collected
Sex, age
Questionnaire name/set of questions
Set of questions
Administration method
Face-to-face interview

Medication

Information collected
Drug use
Questionnaire name/set of questions
Set of questions
Antibiotics
Last treatment and frequency collected
Administration method
Face-to-face interview

Health status

Information collected
Health status, including cognitive health (for very preterm)
Administration method
Face-to-face interview
Measurements
Various

Biological samples and laboratory measurements

Samples collected
Feces, oral swabs (for a subset)
Number of samples
499

Microbiome

Microbial material
16S rDNA (V3-V4)
Number of samples/number of individuals
499
Library source and library selection
Metagenome (following the 16S Metagenomic Sequencing Library Preparation protocol by Illumina)
Medium/tissue
Faeces/oral swabs
Sampling collection method
Sterile collection tube and swabs
Time spent in room temperature
Few minutes
Sequencing platform
Illumina MiSeq
Read length/depth
2x250 bp; 2x300 bp
Further details
True sequencing
Preservation method
No, immediately -20°C until delivery to the lab (where stored at -80°C)
Information on type of meal last eaten prior to sample extraction available
no